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US 7,252,968 B2Granted
Chromatin regulator genes
AssigneeBoehringer Ingelheim International GmbH
InventorsThomas Jenuwein, Götz Laible, Donal O'Carroll, Frank Eisenhaber, Stephen Rea
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Abstract
The invention concerns the deregulation of the chromatin-regulator genes which have a SET domain, such deregulation being of importance in certain cancer conditions. These genes can be used in the diagnosis and therapy of such conditions.
Claims13
An isolated nucleic acid molecule comprising a polynucleotide selected from the group consisting of:
- (a) a polynucleotide encoding amino acids 1 to 746 of SEQ ID NO:2;
- (b) a polynucleotide enoding a protein containing amino acids of SEQ ID NO:
- 2, wherein a stop codon shortens the protein by 47 C-terminal amino acids;
- and with
- a polynucleotide encoding a protein containing amino acids 1–699 of SEQ ID NO:2;
- and
- (c) a polynucleotide complementary to the polynucleotide of (a) or (b).
4 more elements
Dependencies are inferred from the claim text.