Modulation of tetraspanin function
AssigneeNovartis Vaccines and Diagnostics, Inc.
InventorsMartino Bolognesi, Guido Grandi
Life of this patent
Estimating the term…
Abstract
Tetraspanins have been found to dimerise. Methods for inhibiting or promoting the dimerisation of tetraspanins are provided, which may involve protein engineering of the tetraspanins themselves, or may rely on other molecules.
Claims14
A method for modulating the ability of a tetraspanin protein to form a dimer with the wild-type tetraspanin, comprising the step of mutating at least one of the amino acids corresponding to human CD81 (SEQ ID NO:1) residues 114, 119, 123, 125, 126, 129, 142, 146, 149, 150, 153, 154, 197, 198, 199 and 200;
- wherein said mutated tetraspanin protein has a decreased ability to form a dimer with the wild-type tetraspanin.
A method for modulating the ability of a tetraspanin CD81 protein to form a dimer with a wild-type tetraspanin, comprising the step of mutating at least one of the amino acids corresponding to human CD81 (SEQ ID NO:1) residues 114, 119, 123, 125, 126, 129, 142, 146, 149, 150, 153, 154, 197, 198, 199 and 200;
- wherein said tetraspanin CD81 protein has a decreased ability to form a dimer with the wild-type tetraspanin.
A mutant tetraspanin protein which, compared with the wild-type protein, has a decreased ability to form a dimer with the wild-type protein.
Dependencies are inferred from the claim text.