Method of detecting colon cancer
AssigneeLoma Linda University Adventist Health Sciences Center
InventorsKeshab D. Pant, John D. McCracken, Omar Fagoaga, Wayne Kelln, Sandra Nehlsen-Cannarella
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Abstract
An immunological assay and kit for colon cancer screening is disclosed. Fecal glycoproteins are extracted from individual samples such that immunogenicity is maintained. The purified fecal glycoproteins are reacted with antibodies to Colon and Ovarian Tumor Antigen (COTA). The mucin antigen COTA is specifically present in colorectal cancer tissue and not in normal colons. The amount of COTA in the fecal sample is determined and used to indicate the presence of colon cancer.
Claims5
A kit for screening for colon cancer comprising:
- an anti-COTA capture antibody bound to a solid support;
- purified human COTA antigen;
- and
- a vial containing a preservative solution for collection of a fecal sample, wherein the preservative comprises ethanol and formalin at a concentration such that bacterial growth is retarded and extraneous fecal matter is precipitated while maintaining immunogenicity of glycoproteins in the fecal sample.
Dependencies are inferred from the claim text.