Back to results
US 7,252,944 B2Granted
Methods and compositions for modulating cell proliferation
AssigneeIrm LLC
InventorsKavita Shah, Sungjoon Kim
Life of this patent
Estimating the term…
Abstract
This invention provides methods for identifying novel SHMT modulators. The methods comprise first screening test agents for modulators of p38 activity and then further screening the identified modulating agents for modulators of SHMT enzyme activity. The invention further provides methods and pharmaceutical compositions for modulating cellular proliferation and for treating tumors using the novel SHMT modulators.
Claims9
A method for identifying an agent that modulates serine hydroxymethyltransferase (SHMT) activity, the method comprising:
- (a) assaying a biological activity of p38 or its homolog in the presence of test agents to identify one or more modulating agents that modulate the biological activity of p38;
- and
- (b) testing one or more of the modulating agents for ability to modulate enzymatic activity of SHMT;
- thereby identifying an SHMT modulator that modulates SHMT activity.
1 more element
Dependencies are inferred from the claim text.