Methods and devices for producing a polymer at a location of a substrate

A method for determining relative misalignment of a fluid deposition device during polymer production on the surface of a substrate, said method comprising:

• (a) depositing a fluid droplet containing a first monomer labeled with a first detectable label from a fluid deposition device onto an intended deposition location of a substrate surface to produce a polymer at said intended deposition location, wherein said intended deposition location comprises a second monomer labeled with a second detectable label and said first and second detectable labels are distinguishable from each other;
• and
• (b) detecting said first and second detectable labels to determine any relative misalignment between said fluid deposition device and said intended deposition location to determine relative misalignment of said fluid deposition device during polymer production on the surface of said substrate.