Rapid setting calcium phosphate cements
AssigneeSkeletal Kinetics, LLC
InventorsBrent R. Constantz, David Delaney, Duran Yetkinler
Life of this patent
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Abstract
Methods are provided for producing compositions, e.g. pastes or clays, which rapidly set into high-strength calcium phosphate products. In the subject methods, dry reactants that include calcium and phosphate sources, as well as a monovalent cation dihydrogen phosphate salt, are combined with a setting fluid and the combined reactants are mixed to produce the settable composition. A feature of the invention is that cements rapidly set into high strength product compositions. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including hard tissue repair applications.
Claims14
A method of producing a flowable composition that rapidly sets into a solid strong calcium phosphate containing product, said method comprising combining:
- (a) a water soluble silicate setting fluid;
- and
- (b) dry reactants comprising:
- (i) calcium and a phosphate sources;
- and
- (ii) a monovalent cation dihydrogen phosphate salt which is NaH2PO4 or NaH2PO4.H2O;
- in a ratio of (a) to (b) sufficient to produce said flowable composition that has a setting value of at least about 50 Newtons in 3 minutes.
A kit for use in preparing a composition that sets in an in vivo environment into a solid strong calcium phosphate containing product, said kit comprising:
- (a) dry reactants comprising:
- (i) calcium and a phosphate sources;
- and
- (ii) a monovalent cation dihydrogen phosphate salt which is NaH2PO4 or NaH2PO4.H2O;
- and
- (b) a water soluble silicate setting fluid or components for producing the same.
Dependencies are inferred from the claim text.