Loading patent…
AssigneeClemson University Research Foundation (CURF)
InventorsNarendra R. Vyavahare, Jason C. Isenburg, Dan T. Simionescu
Estimating the term…
A method and product are provided for the treatment of connective tissue weakened due to destruction of tissue architecture, and in particular due to elastin degradation. The treatment agents employ certain unique properties of phenolic compounds to develop a protocol for reducing elastin degradation, such as that occurring during aneurysm formation in vasculature. According to the invention, elastin can be stabilized in vivo and destruction of connective tissue, such as that leading to life-threatening aneurysms in vasculature, can be tempered or halted all together. The treatment agents can be delivered or administered acutely or chronically according to various delivery methods, including sustained release methods incorporating perivascular or endovascular patches, use of microsphere carriers, hydrogels, or osmotic pumps.
A method for stabilizing connective tissue comprising applying a composition including a phenolic compound directly to connective tissue, the composition having a pH between about 4 and about 9, wherein the connective tissue comprises elastin and wherein the phenolic compound comprises a hydrophobic core that includes more than one phenolic group.
A method for stabilizing the structural architecture of a blood vessel comprising delivering a phenolic compound to the connective tissue of the blood vessel wall, wherein the phenolic compound is a component of a composition having a pH of between about 4 and about 9, wherein the connective tissue includes elastin, wherein the phenolic compound comprises a hydrophobic core that includes more than one phenolic group.
A composition for stabilizing the structural architecture of connective tissue comprising:
Dependencies are inferred from the claim text.