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US 7,252,826 B2Granted
Modified mite allergen and pharmaceutical uses thereof
AssigneeGenMont Biotech Inc.
InventorsChing-Hsiang Hsu, Wei-Chih Su
Life of this patent
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Abstract
The present invention provides a modified Dermatophagoides pteronyssinus allergen Der p 5 protein which has ability to inhibit IgE binding when exposed against to the antigen. A method for treating allergy comprising administrating a therapeutically effective dose of the modified D. pteronyssinus allergen Der p 5 protein to a subject suffering from allergy Der p 5 is also provided.
Claims8
A modified Dermatophagoides pteronyssinus allergen Der p 5 protein, wherein at least one of amino acid residues 44, 77, 99, and 103 of wild-type D. pteronyssinus allergen Der p 5 protein of SEQ ID NO.2 is substituted with alanine.
Dependencies are inferred from the claim text.