Viruses for the treatment of cellular proliferative disorders
AssigneeOncolytics Biotech Inc.
InventorsMatthew C. Coffey, Bradley G. Thompson
Life of this patent
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Abstract
Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering a immunosuppressive agent.
Claims19
A method for treating a neoplasm in a mammal, comprising the steps of:
- (a) selecting a mammal with a neoplasm wherein cells of the neoplasm are unable to activate a PKR-mediated response to viral infection;
- and
- (b) administering to the cells of the neoplasm an effective amount of at least one modified HSV under conditions that result in substantial lysis of the cells of the neoplasm, wherein in the modified HSV, the γ134.5 gene is lacking, inhibited or mutated such that PKR activation is not blocked.
Dependencies are inferred from the claim text.