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AssigneeClearant, Inc.
InventorsShirley I. Miekka, Wilson Burgess, William N. Drohan, Martin J. Macphee, Randall S. Kent, David M. Mann, Yuri Griko
Estimating the term…
Methods are disclosed for sterilizing preparations containing albumin to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. These methods involve sterilizing preparations containing albumin, such as plasma protein fractions, with irradiation.
A method for inactivating at least one biological contaminant or pathogen in a preparation containing albumin comprising irradiating said preparation with gamma radiation at a rate of greater than 3.0 kGy/hr for a time effective to inactivate at least one biological contaminant or pathogen in said preparation.
A method for inactivating at least one biological contaminant or pathogen in a plasma protein fraction preparation comprising irradiating said preparation with gamma radiation at a rate greater than 3.0 kGy/hr for a time effective to inactivate at least one biological contaminant or pathogen in said preparation.
A method for inactivating at least one biological contaminant or pathogen in a plasma protein fraction preparation comprising reducing the temperature of said preparation to a level effective to protect said preparation from gamma irradiation;
Dependencies are inferred from the claim text.