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US 7,250,533 B2Granted
Process for preparing Cinacalcet hydrochloride
AssigneeTeva Pharmaceutical Industries Ltd.
InventorsRevital Lifshitz-Liron, Amihai Eisenstadt, Shlomit Wizel, Sharon Avhar-Maydan, Yuriy Raizi, Revital Ramaty
Life of this patent
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Abstract
Processes for preparing cinacalcet are provided.
Claims45
A process for preparing cinacalcet base, comprising:
- providing compound V of the structure:
- converting the hydroxyl moiety of compound V into a good leaving group wherein a good leaving group is a conjugate base to obtain compound VI of the structure:
- and combining compound VI with (R)-1-Naphthylethylamine (NEA) in the presence of a base at a temperature of about 50° C. to about 120° C. to obtain cinacalcet base.
Dependencies are inferred from the claim text.