Back to results
US 7,250,154 B2Granted
Radio-opaque polymeric biomaterials
AssigneeRutgers, The State University
InventorsJoachim B. Kohn, Durgadas Bolikal, Sanyong M. Pendharkar
Life of this patent
Estimating the term…
Abstract
A radio-opaque dihydroxy compound substituted with at least one bromine or iodine atom. Radio-opaque medical implants and drug delivery devices and methods for therapeutic site-specific or systemic drug delivery comprising implanting in the body of a patient are also disclosed.
Claims25
A radio-opaque dihydroxy compound substituted with at least one bromine or iodine atom, having the structure:
- wherein R5 and R6 are each independently selected from the group consisting of H, Br, I and straight and branched alkyl groups having up to 18 carbon atoms, R0 is selected from the group consisting of —CH═CH—, —CHJ1-CHJ2- and (—CH2—)m and R15 is selected from the group consisting of —CH═CH—, (—CH2—)c and —CHJ1-CHJ2-, wherein J1 and J2 are independently Br or I;
- c and m are independently between 0 and 8, inclusive;
- each X2 is independently I or Br;
- Y2 is 1 or 2;
- and Z is selected from the group consisting of hydrogen, a free carboxylic acid group or an ester or amide thereof, said ester or amide being selected from the group consisting of straight and branched alkyl and alkylaryl groups containing up to 18 carbon atoms and esters and amides of biologically and pharmaceutically active compounds.
2 more elements
Dependencies are inferred from the claim text.