Mouse model for psoriasis and psoriatic arthritis
AssigneeBoehringer Ingelheim International GmbH
InventorsRainer Zenz, Erwin Wagner
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Abstract
A mouse that is deficient for c-Jun and JunB in the epidermis or in which deletion of c-Jun and JunB can be specifically induced in the epidermis, and methods for obtaining such mice. The mice and keratinocytes derived therefrom are useful as an animal model for psoriasis and psoriatic arthritis.
Claims19
A transgenic mouse whose genome comprises deletions of c-Jun and JunB genes in keratinocytes of the epidermis, wherein said transgenic mouse is a double knockout for said c-Jun and JunB genes in keratinocytes of the epidermis following keratinocyte-specific activation and expression of a site-specific recombination enzyme, and wherein said transgenic mouse exhibits one or more characteristics selected from the group consisting of an abnormally thickened epidermis, parakeratosis, hyperkeratosis, fingerlike epidermal projections into the dermis, granulocytic infiltrates into the joint region, rete ridges, epidermal microabscesses, intraepidermal T-cells, increased numbers of neutrophils, macrophages in the dermis, or combinations thereof.
A method comprising
- (a) administering an agent to a transgenic mouse whose genome comprises deletions of c-Jun and JunB genes in keratinocytes of the epidermis, wherein said transgenic mouse is a double knockout for said c-Jun and JunB genes in keratinocytes of the epidermis following keratinocyte-specific activation and expression of a site-specific recombination enzyme, and wherein said transgenic mouse exhibits one or more characteristics selected from the group consisting of an abnormally thickened epidermis, parakeratosis, hyperkeratosis, fingerlike epidermal projections into the dermis, granulocytic infiltrates into the joint region, rete ridges, epidermal microabscesses, intraepidermal T-cells, increased numbers of neutrophils, macrophages in the dermis, or combinations thereof;
- and
- (b) measuring the effect of said agent on said one or more characteristics of said mouse.
Dependencies are inferred from the claim text.