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US 7,247,745 B2Granted
Process for preparing 1,5-diaryl-3-substituted pyrazoles
AssigneeOrtho-McNeil Pharmaceutical, Inc.
InventorsAhmed F. Abdel-Magid, Bruce D. Harris, Cynthia A. Maryanoff
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Abstract
A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III which is reacted with a compound of formula IV to form a compound of V and reacting with an alcohol to form the corresponding ester of formula VI and reacting the ester with N-methylhydroxylamine.
Claims3
A process of preparing a compound of formula III
- wherein R3 and R4 are the same or different and are individually selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, amino, acetamido, phenyl, halo, hydroxy, lower alkylsulfonyl, lower alkylthio, nitro, trifluoromethyl, omega-trifluoromethyl lower alkoxy, or where R3, R4 taken together with the phenyl group to which they are attached, form a naphthyl or substituted naphthyl group
- comprising reacting a compound of formula II
- wherein R3 and R4 are as described above, with succinic anhydride and an alkoxide base.
Dependencies are inferred from the claim text.