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US 7,247,728 B2Granted
Bicyclic N-arylamides
AssigneeBayer HealthCare LLC
InventorsJoachim Luithle, Frank-Gerhard Böss, Christina Erb, Timo Flessner, Martin Hendrix, Marja van Kampen, Christoph Methfessel
Life of this patent
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Abstract
This application relates to bicyclic N-aryl amides of the formula R1 is a 1-aza-bicyclo[3.2.1]octyl group, a 1-aza-bicyclo[2.2.2]oct-3-yl; R2 is an optionally sustituted 8- to 10- membered heteroaryl, naphthyl, or azulenyl group; and R3 is H or (C1C6)alkyl; or a salt, solvate, or solvate of a salt of these compounds. A process for preparing these compounds, medicaments containing them, and methods for using them in treatment are also disclosed and claimed.
Claims7
A compound of the general formula (I)
- in which
- R1 is a 1-aza-bicyclo[3.2.1]octyl, 1-aza-bicyclo[3.3.1]nonyl, or 1-aza-bicyclo[2.2.2]oct-3-yl, wherein the bicycloalkyl radical is optionally substituted by (C1–C6)-alkyl,
- R2 is 8- to 10-membered heteroaryl, naphthyl or azulenyl, where the rings are optionally substituted by radicals selected from the group of hydrogen, halogen, formyl, carbamoyl, cyano, trifluoromethyl, trifluoromethoxy, nitro, (C1–C6)-alkyl, (C1–C6)-alkoxy, (C1–C6)-alkylthio,
- and
- R3 hydrogen or (C1–C6)-alkyl,
- or their salts, solvates and solvates of the salts.
3 more elements
Dependencies are inferred from the claim text.