Back to results
US 7,247,727 B2Granted
Azaindole thiazolinones
AssigneeHoffmann-La Roche Inc.
InventorsShaoqing Chen, Achyutharao Sidduri
Life of this patent
Estimating the term…
Abstract
Azaindole thiazolinone derivatives which demonstrate CDK1 and CDK2 antiproliferative activities and are useful as anti-cancer agents.
Claims46
A compound of the formula:
- wherein
- R1 is selected from hydrogen, lower alkyl, hydroxy-lower alkyl, cyclo-lower alkyl, lower alkoxy-lower alkyl and R2—(X)n;
- where n is an integer from 0 to 1;
- X is selected from lower alkylene, hydroxy-loweralkylene, cyclo-loweralkylene, lower alkoxy-lower alkylene and lower alkanoyloxy-lower alkylene;
- R2 is
- is selected from an aryl ring, a 4 to 6 membered heterocycloalkyl ring containing from 3 to 5 carbon atoms and from 1 to 2 hetero atoms selected from the group consisting of oxygen, nitrogen and sulfur;
- and a 5 or 6 membered heteroaromatic ring containing from 1 to 2 hetero atoms selected from the group consisting of oxygen, sulfur and nitrogen;
- R5 and R6 are independently selected from the group consisting of hydroxy, hydroxy-lower alkyl, hydrogen, lower alkyl, halogen, perfluro lower alkyl and lower alkoxy, and n is an integer from 0 to 1;
- and
- pharmaceutically acceptable salts thereof.
7 more elements
Dependencies are inferred from the claim text.