Polynucleotide encoding a novel human serpin secreted from lymphoid cells, LSI-01
AssigneeBristol-Myers Squibb Company
InventorsJian Chen, Thomas Nelson, Daniel L. Cheney
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Abstract
The present invention provides novel polynucleotides encoding LSI-01 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LSI-01 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
Claims15
An isolated nucleic acid molecule consisting of a polynucleotide sequence selected from the group consisting of:
- (a) an isolated polynucleotide encoding a polypeptide consisting of amino acids 1 to 435 of SEQ ID NO:2;
- (b) an isolated polynucleotide encoding a polypeptide consisting of amino acids 2 to 435 of SEQ ID NO:2;
- and
- (c) an isolated polynucleotide encoding a mature polypeptide consisting of amino acids 39 to 435 of SEQ ID NO:2.
An isolated polynucleotide consisting of the polynucleotide encoding the LSI-01 polypeptide as encoded by the cDNA clone contained in ATCC Deposit No:
- PTA-2766.
Dependencies are inferred from the claim text.