Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the HER-2/neu oncogene is associated
AssigneeUniversity of Washington
InventorsMartin A Cheever, Mary L Disis
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Abstract
Methods for the detection, monitoring and treatment of malignancies in which the HER-2/neu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2/neu protein, or detection of immunocomplexes formed between the HER-2/neu protein and antibodies in body fluid, allows the diagnosis of the presence of a malignancy in which the HER-2/neu oncogene is associated. The present invention also discloses methods and compositions, including peptides, for treating such malignancies.
Claims5
An isolated peptide consisting of the amino acid sequence of His-Leu-Tyr-Gln-Gly-Cys-Gln-Val-Val (Seq. ID No. 1).
An isolated peptide consisting of the amino acid sequence of Pro-Leu-Gln-Pro-Glu-Gln-Leu-Gln-Val (Seq. ID No. 2).
An isolated peptide consisting of the amino acid sequence of Cys-Leu-Thr-Ser-Thr-Val-Gln-Leu-Val (Seq. ID No. 7).
An isolated peptide consisting of the amino acid sequence of Val-Leu-Val-Lys-Ser-Pro-Asn-His-Val (Seq. ID No. 9).
An isolated peptide consisting of the amino acid sequence of Gln-Leu-Met-Pro-Tyr-Gly-Cys-Leu-Leu (Seq. ID No. 15).
Dependencies are inferred from the claim text.