3,4-disubstituted benzamidines and benzylamines, and analogues thereof, useful as serine protease inhibitors

A compound of Formula (I):

• or a stereoisomer or a pharmaceutically acceptable salt or solvate form thereof, wherein:
• ring A is phenyl;
• wherein the phenyl is further substituted with 0-2 R6;
• X is NR7;
• R1 is —CH2NR1aR1b or —C(═NR1c)NHR1d;
• R1a is, independently at each occurrence, H or C1-C3 alkyl;
• R1b is, independently at each occurrence, H or C1-C3 alkyl;
• R1c is, independently at each occurrence, H or C1-C4 alkyl;
• R1d is, independently at each occurrence, H or C1-C4 alkyl;
• R2 is Y-Z-R2a;
• Y is a bond, C1-C8 alkylene substituted with 0-3 R2d, C2-C8 alkenylene substituted with 0-3 R2d, or C2-C8 alkynylene substituted with 0-3 R2d;
• Z is absent, —O—, —NR2b—, —NR2bC(O)—, —NR2bC(O)O—, —NR2bC(O)NR2b—, —NR2bS(O)2—, —S(O)2—, —C(O)O—, —C(O)NR2b—, or —C(O)—;
• provided that X—Y-Z do not combine to form a N—O bond;
• R2a is, independently at each occurrence, H, R2c, C1-C6 alkyl substituted with 1 R2c, or C1-C8 alkyl substituted with 0-3 R2d;
• R2b is, independently at each occurrence, H, C1-C3 alkyl or phenyl;
• R2c is, independently at each occurrence, C3-C6 monocycloalkyl substituted with 0-3 R2e, phenyl substituted with 0-3 R2e, or 5-6 membered unsaturated, partially unsaturated or saturated heterocycle consisting of carbon atoms and 1-4 heteratoms independently chosen from O, N, and S, and substituted with 0-3 R2e;
• R2d is, independently at each occurrence, halogen, —CF3, C1-C6 alkyl, or C1-C6 alkoxy;
• R2e is, independently at each occurrence, halogen, —CF3, C1-C6 alkyl, C1-C6 alkoxy, —CN, —NO2, ═O, —OR2f, —OC(O)R2f, —OC(O)OR2f, —OC(O)NR2bR2f, —NR2bR2f, —NR2bC(O)R2f, —NR2bC(O)OR2f, —NR2bC(O)NR2bR2f, —NR2bS(O)2R2f, —NR2bS(O)2NR2bR2f, —C(O)R2f, —C(O)OR2f, —C(O)NR2bR2f, —C(O)NHS(O)2R2f, —S(O)2NHC(O)R2f, or —C(O)NHC(O)R2f;
• R2f is, independently at each ocurrence, H, C1-C6 alkyl, phenyl, benzyl, or CF3;
• R3 is H, F, or CH3;
• R4 is H, F, or CH3;
• alternatively, R3 and R4 are taken together to form —CH2CH2—, —CH2CH2CH2—, —CH2CH2CH2CH2—, or —CH2CH2 CH2CH2CH2—;
• R5 is:
• ring B is C6-C10 aryl;
• R6 is, independently at each ocurrence, H, C1-C3 alkyl, halogen, —CF3, —OH, C1-C3 alkoxy, or —OCF3;
• R7 is H, C1-C6 alkyl, phenyl, benzyl, or phenethyl;
• R8 is, independently at each ocurrence, H, halogen, —CF3, C1-C6 alkyl, or C1-C6 alkoxy;
• R9 is, independently at each ocurrence, H, halogen, —CF3, C1-C6 alkyl, or C1-C6 alkoxy;
• and
• R10 is, independently at each ocurrence, H, halogen, —CF3, C1-C6 alkyl, or C1-C6 alkoxy;
• provided that:
• when B is phenyl, R2 is other than H or C1-C3 alkyl.