Pharmaceutical composition
AssigneeTakeda Pharmaceutical Company Limited
InventorsNaoki Asakawa, Masao Nagao, Jun Sato
Life of this patent
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Abstract
The present invention relates to a pharmaceutical composition containing a cycloalkene compound, a salt thereof or a prodrug thereof, and a nonionic surfactant and/or a cyclodextrin derivative readily soluble in water, and a method for improving solubility, stability or coloring property of the compound, a salt thereof or a prodrug thereof.
Claims9
A pharmaceutical composition comprising (i) d-ethyl 6-[N-(2-chloro-4-fouorophenyl)sulfamoyl]-1-cyclohexene-1-carboxylate, a salt thereof or a prodrug thereof, (ii) at least one cyclodextrin derivative selected from the group consisting of maltosyl-β-cyclodextrin, glucosyl-β-cyclodextrin, hydroxypropyl-β-cyclodextrin and hydroxyethyl-β-cyclodextrin, and (iii) water.
A pharmaceutical composition (i) d-ethyl 6-[N-(2-chloro-4-flourophenyl)sulfamoyl]-1-cyclohexene-1-carboxylate, a salt therof or a prodrug thereof, (ii) at least on cyclodextrin derivative selected from the group consisting of hydroxypropyl-β-cyclodextrin and hydroxyethyl-β-cyclodextrin, and (iii) water.
A method for improving solubility in water of d-ethyl 6-[N-(2-chloro-4-flourophenyl)sulfamoyl]-1-cyclohexene-1-carboxylate, a salt thereof or a prodrug thereof, which comprises mixing said compound, a salt thereof or a prodrug thereof with at least one cyclodextrin derivative selected from the group consisting of maltosyl-β-cyclodextrin, glucosyl-β-cyclodextrin, hydroxypropyl-β-cyclodextrin and hydroxyethyl-β-cyclodextrin.
Dependencies are inferred from the claim text.