β-benzyloxyaspartate derivatives with amino group on benzene ring
AssigneeSuntory Limited
InventorKeiko Shimamoto
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Abstract
L-threo-β-benzyloxyaspartate derivatives having a substituent on the benzene ring, represented by the following formula (1): wherein R is hydrogen, a linear or branched lower aliphatic acyl group with the acyl portion optionally substituted, an alicyclic acyl group, an aromatic acyl group with a substituent on the aromatic ring, an amino acid-derived group or a biotin derivative-derived group, having an amino substituent on the benzene ring, and salts thereof, which can easily bind to affinity column chromatography carriers as ligands of glutamate transporter proteins.
Claims15
An L-threo-β-benzyloxyaspartate derivative having a substituent on the benzene ring, represented by the following formula (1):
- or a salt thereof,
- wherein R is hydrogen, a linear or branched lower aliphatic acyl group with the acyl portion optionally substituted, an alicyclic acyl group, an aromatic acyl group with a substituent on the aromatic ring, an amino acid-derived group or a biotin derivative-derived group.
A compound represented by the following formula (7):
- wherein Boc represents t-butoxycarbonyl and TBS represents t-butyldimethylsilyl.
Dependencies are inferred from the claim text.