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US 7,247,651 B2Granted
2,7-substituted indoles
AssigneeRoche Palo Alto LLC
InventorsAnn Marie Madera, Robert James Weikert
Life of this patent
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Abstract
The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R1, R2, R3, R4, and n are those defined herein. The present invention also provides compositions comprising, methods for using, and methods for preparing Compound of Formula I.
Claims25
A compound of the formula:
- or a pharmaceutically acceptable salt thereof,
- wherein
- n is 0, 1 or 2;
- p is 1 or 2;
- R1 is aryl or heteroaryl;
- R2 is a heterocyclyl;
- R3 is hydrogen, alkyl, or —C(═O)—R5, where R5 is alkyl, alkoxy, aryl, or aryloxy;
- and
- each R4 is independently hydrogen, hydroxy, cyano, alkyl, alkoxy, thioalkyl, alkylthio, halo, haloalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, alkylcarbonyl, alkylsulfonyl, arylsulfonyl, haloalkylsulfonyl, amino, alkylamino, dialkylamino, alkyl(aryl)amino, alkylaminocarbonyl, alkylcarbonylamino, alkylcarbonyl(alkylamino), alkylaminosulfonyl, alkylsulfonylamino or methylenedioxyhydrogen, alkyl, alkoxy, halo, or haloalkyl.
6 more elements
Dependencies are inferred from the claim text.