US 7,247,646 B2 · Benzopyranone compounds, compositions thereof, and methods of treatment therewith

Abstract

Benzopyranone Compounds having the following structure: wherein R1, R2, X, Y and n are as defined herein, are disclosed. The Benzopyranone Compounds are useful for treating or preventing a bone-resorbing disease, a neoplastic disease, arthritis, a disease exacerbated by the presence of estrogen or a disease improved by the presence of estrogen, comprising administering an effective amount of a Benzopyranone Compound to a patient in need of the treating or preventing; activating the function of estrogen receptor (“ER”) in a bone cell; inhibiting the function of ER in a cancer cell; inhibiting the expression of interleukin-6 (“IL-6”) in a cell; and inhibiting the growth of a neoplastic cell, comprising contacting the cell with an effective amount of a Benzopyranone Compound.

Claims4

Dependent claims

A compound having the structure:

or a pharmaceutically acceptable salt thereof,
wherein:
X and Y are independently hydrogen, halogen or (halo)(C1-6alkyl);
n is 1, 2 or 3;
and
either:
(a) R1 is hydrogen and R2 is halogen, hydroxy, —(C1-6alkyl), vinyl, —(C2-6alkynyl), —C(O)O(C1-6alkyl), -(hydroxy)(C1-6alkyl), -(amino)(C1-6alkyl), —(CH2)m—O—(C1-6alkyl), —C(O)(C1-6alkyl), —(CH2)m-phenyl, -(3- to 7-membered monocyclic heterocycle), —COOH, —C(O)H or —CN;
(b) R2 is hydrogen and R1 is halogen, hydroxy, —(C1-6alkyl), —(C2-6alkenyl)-(C2-6alkynyl), —C(O)O(C1-6alkyl), -(hydroxy)(C1-6alkyl), -(amino)(C1-6alkyl), —(CH2)m—O—(C1-6alkyl), —C(O)(C1-6alkyl), —(CH2)m-phenyl, -(3- to 7-membered monocyclic heterocycle), —COOH, —C(O)H or —CN;
or
(c) R1 and R2 are —CH3.

7 more elements

Dependencies are inferred from the claim text.

Benzopyranone compounds, compositions thereof, and methods of treatment therewith

Life of this patent

Benzopyranone compounds, compositions thereof, and methods of treatment therewith

Life of this patent

Abstract

Claims4