Dihydropyridine derivatives

A dihydropyridine of formula (1) or a pharmaceutically acceptable salt thereof:

• wherein A represents a group of formula (2), or 1-naphthyl, 2-naphthyl, thiophene-3-yl, thiophene-2-yl, furan-3-yl, furan-2-yl, pyridine-4-yl, pyridine-3-yl, pyridine-2-yl, indole-2-yl or indole-3-yl group:
• wherein R1, R2, R3, R4 and R5 may be the same or different from each other and each represent hydrogen atom, a halogen atom, hydroxyl group, carboxyl group, amino group, cyano group, nitro group, a lower alkyl group, a lower alkoxyl group, a lower alkenyl group, a lower alkynyl group, a lower alkylamino group, a lower alkylthio group, a lower alkanoyl group, a lower alkoxycarbonyl group, a hydroxy-lower alkyl group, a hydroxy-lower alkoxyl group, a hydroxy-lower alkenyl group, a halogeno-lower alkyl group, a halogeno-lower alkoxyl group, a halogeno-lower alkenyl group, an aryl group, an aryl-lower alkoxyl group or an aroyl group;
• B represents cyano group, carboxyl group, or a group of formula (3):
• wherein R6 and R7 may be the same or different from each other and each represent hydrogen atom, a lower alkyl group, an amino-lower alkyl group, an amino-lower alkyl group substituted with one or two lower alkyl groups, a carboxy-lower alkyl group, a hydroxy-lower alkyl group, a lower cycloalkyl group, an amino-lower alkenyl group, a carboxy-lower alkenyl group, a hydroxy-lower alkenyl group, an aryl group, a pyridyl group, a furyl group, an aryl-lower alkyl group, a pyridyl-lower alkyl group, a furyl-lower alkyl group, an aryl-lower alkenyl group, or an aryl-lower alkyloxycarbonyl-lower alkyl group;
• C and E may be the same or different from each other and each represent hydrogen atom;
• a lower alkyl group;
• dimethoxymethyl group;
• cyano group;
• a hydroxy-lower alkyl group;
• a carboxy-lower alkyl group;
• a halogeno-lower alkyl group;
• an amino-lower alkyl group, in which the amino group may be substituted with one or two of a lower alkyl group, a lower cycloalkyl group, an aryl group or an aryl-lower alkyl group;
• an azido-lower alkyl group;
• an aryl group;
• a pyridyl group;
• a furyl group;
• an aryl-lower alkyl group;
• a pyridyl-lower alkyl group;
• a furyl-lower alkyl group;
• a pyridyl-lower alkoxymethyl group;
• a furyl-lower alkoxymethyl group;
• a pyridinylethoxymethyl group;
• or a carbamoyl-lower alkyl group, in which the carbamoyl group may be substituted with one or two of a lower alkyl group, a lower cycloalkyl group, an aryl group or an aryl-lower alkyl group;
• a piperidinylethoxymethyl group;
• wherein said lower alkyl portion of said lower alkyl group, hydroxy-lower alkyl group, carboxy-lower alkyl group, halogeno-lower alkyl group, amino-lower alkyl group, azido-lower alkyl group, aryl-lower alkyl group, and carbamoyl-lower alkyl group may contain a hetero atom, which is selected from the group consisting of oxygen and nitrogen;
• D represents a hydrogen atom;
• F represents a group of formula (4):
• wherein G and H each represent phenyl group, and I represents hydrogen atom or hydroxyl group;
• X represents an interatomic bond, —CH2—, —CH2CH2—, —CH═CH— or —C≡C—, and
• Y represents an alkylene group having 2 or 3 carbon atoms.