Ester derivatives of a decahydroisoquinoline-3-carboxylic acid as analgestics
AssigneeEli Lilly and Company
InventorPaul Leslie Ornstein
Life of this patent
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Abstract
Thus, the present invention provides compounds of formula (I) The present invention further provides the use of a compound of formula (I) for the manufacture of a medicament for the treatment of a neurological disorder. The present invention further provides the use of a compound of formula (I) for the manufacture of a medicament for the treatment of pain or migraine
Claims20
A compound of the formula:
- wherein R represents C2-C10 alkyl, or a pharmaceutically acceptable salt thereof.
A salt selected from the group consisting of (3S,4aR,6R,8aR)-6-[2-(1H-Tetrazol-5-yl)-ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydro-isoquinoline-3-carboxylic acid 2-ethyl-butyl ester trifluoroacetate salt;
- (3S,4aR,6R,8aR)-6-[2-(1H-Tetrazol-5-yl)-ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydro-isoquinoline-3-carboxylic acid isobutyl ester trifluoroacetate salt;
- (3S,4aR,6R,8aR)-6-[2-(1H-Tetrazol-5-yl)-ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydro-isoquinoline-3-carboxylic acid 3-methyl butyl ester trifluoroacetate salt;
- (3S,4aR,6R,8aR)-6-[2-(1H-Tetrazol-5-yl)-ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydro-isoquinoline-3-carboxylic acid decyl ester trifluoroacetate salt;
- and (3S,4aR,6R,8aR)-6-[2-(1H-Tetrazol-5-yl)-ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydro-isoquinoline-3-carboxylic acid ethyl ester hydrochloride salt.
A compound which is (3S,4aR,6R,8aR)-6-[2-(1H-Tetrazol-5-yl)-ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydro-isoquinoline-3-carboxylic acid 2-ethyl-butyl ester.
A compound which is (3S,4aR,6R,8aR)-6-[2-(1H-Tetrazol-5-yl)-ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydro-isoquinoline-3-carboxylic acid isobutyl ester.
A compound which is (3S,4aR,6R,8aR)-6-[2-(1H-Tetrazol-5-yl)-ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydro-isoquinoline-3-carboxylic acid 3-methyl butyl ester.
A compound which is (3S,4aR,6R,8aR)-6-[2-(1H-Tetrazol-5-yl)-ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydro-isoquinoline-3-carboxylic acid decyl ester.
A compound which is (3S,4aR,6R,8aR)-6-[2-(1H-Tetrazol-5-yl)-ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydro-isoquinoline-3-carboxylic acid ethyl ester.
(3S,4aR,6R,8aR)-6-[2-(1H-Tetrazol-5-yl)-ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydro-isoquinoline-3-carboxylic acid methyl ester, or a pharmaceutically acceptable salt thereof, in isolated form.
A pharmaceutical composition which comprises a compound of the formula:
- wherein R represents C1-C10 alkyl, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable diluent or carrier.
A method of treating pain, which comprises administering to a patient an effective amount of a compound of the formula:
- wherein R represents C1-C10 alkyl, or a pharmaceutically acceptable salt thereof.
A method of treating migraine, which comprises administering to a patient an effective amount of a compound of the formula:
- wherein R represents C1-C10 alkyl, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.