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US 7,247,643 B2Granted
8-aza-bicyclo (3.2.1) octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
AssigneeNeuroSearch A/S
InventorsDan Peters, Elsebet Østergaard Nielsen, Gunnar M. Olsen, Jørgen Scheel-Krüger
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Abstract
This invention relates to novel 8-aza-bicyclop[3.2.1]octane derivatives useful as monoamine neurotransmitter re-up-take inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
Claims9
A chemical compound which is an 8-aza-bicyclo[3.2.1]octane derivative of the Formula I:
- or any of its stereoisomers or any mixture of its stereoisomers, or a pharmaceutically acceptable salt thereof,
- wherein
- R represents hydrogen or alkyl;
- R2 represents —CH2—X—Ra;
- wherein X represents —O— or —S—;
- Ra represents phenyl or naphthyl, which phenyl or naphthyl is optionally substituted with one or more substituents selected from the group consisting of:
- halo, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, alkoxy, cycloalkoxy, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, and alkynyl;
- R3 represents heteroaryl;
- which heteroaryl is optionally substituted with one or more substituents selected from the group consisting of:
- halo, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, alkoxy, cycloalkoxy, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, and alkynyl.
7 more elements
Dependencies are inferred from the claim text.