Compounds, derivatives, compositions, preparation and uses

A compound of the following general formula (II):

• or a pharmaceutically acceptable salt, hydrate, prodrug, or mixtures thereof, wherein:
• m is 1 and L is —C(R7R8)—N(R9)— or —N(R9)—C(R7R8)— or m is 2, L is —(N(R9))n, and n is 1;
• R2 is hydrogen, lower alkyl, hydroxy, halogen, nitro, amino, alkylamino, or carboxy;
• R7 and R8 are independently any of an hydrogen, hydroxyl, halogen, or an optionally substituted amino, nitroso, sulfonamide, lower alkyl, lower alkenyl, C1-C6 straight or branched alkanol, cycloalkyl, heterocycloalkyl, heteroaryl, aryl, alkoxy, aryloxy, alkylamino, arylamino, CH2COOH, aralkyl;
• R9 is an hydrogen, hydroxyl, optionally substituted amino, nitroso, methyl or lower alkyl, sulfonamide, lower alkenyl, C1-C6 straight or branched alkanol, cycloalkyl, heterocycloalkyl, heteroaryl, aryl, alkoxy, aryloxy, alkylamino, arylamino, CH2COOH, aralkyl or —C(O)(C1-C10alkyl)N(R5R6);
• and
• R5 and R6 are independently hydrogen, optionally substituted lower alkyl, lower alkenyl, C1-C6 straight or branched alkanol, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkylhalo, alkoxy, aryloxy, alkylamino, arylamino, alkynyl, aryl, benzyl, arylalkyl, CH2COOH, or R5 and R6 taken together form a 4, 5, 6, 7, or 8 membered substituted or unsubstituted heterocycloalkyl or cycloalkyl ring containing 1, 2 or 3 heteroatoms selected from O, N, S and combinations thereof,
• wherein alkyl groups are optionally substituted by mercapto, carboxy, hydroxyl, or phenyl, benzyl or phenylethyl,
• wherein amino groups are optionally substituted by C1-C10 alkyl,
• wherein aryl and heteroaryl groups are optionally substituted in 1-5 positions with halo, haloalkyl, hydroxyl, nitro, trifluoromethyl, C1-C10 straight or branched chain alkyl, C2-C10 straight or branched chain alkenyl, C1-C10 alkoxy, —C(O)—O—(C1-C10 alkyl), carboxy, C2-C10 alkenyloxy, phenoxy, benzyloxy, amino, thiocarbonyl, thioester, cyano, imino, alkylamino, aminoalkyl, sulfhydryl, and thioalkyl, and
• wherein the heterocycloalkyl is a cycloalkyl containing at least 1, 2, 3, or 4 heteroatoms selected from O, N, or S substituted for a ring carbon atom, and may be substituted by or fused to at least one 5 or 6 membered aryl or heteroaryl and/or substituted by at least one of amino, C1 -C10 straight or branched chain alkyl, C1-C10 alkanol, C1-C10 straight or branched chain alkylamino, C1-C10 alkoxy, or C1-C10 alkenyl, or benzyl, or phenyl or phenylethyl.