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US 7,247,628 B2Granted
Cannabinoid receptor ligands and uses thereof
AssigneesPfizer Inc., Pfizer Products Inc.
InventorsRobert L. Dow, Marlys Hammond
Life of this patent
Estimating the term…
Abstract
Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment diseases, conditions and/or disorders herein.
Claims11
A compound of Formula (I)
- wherein
- X is carbon and Y is nitrogen or X is nitrogen and Y is carbon;
- R1 is hydrogen, (C1–C6)alkyl, halogen, or cyano;
- R2 and R3 are each independently (CH2)n-aryl or (CH2)n-heteroaryl, where n is 0, 1 or 2, and where said aryl and said heteroaryl moieties are optionally substituted with one or more substituents;
- L is —C(O)— or —C(R4)(OR5)—, where R4 is hydrogen or (C1–C6)alkyl and R5 is hydrogen, (C1–C6)alkyl, or taken together with R8 or R9 to form a morpholine or morpholin-3-one;
- R6 and R7 are each independently hydrogen or (C1–C6)alkyl, or R6 and R7 taken together form a partially or fully saturated carbocyclic ring;
- and
- R8 and R9 are each independently hydrogen, (C1–C6)alkyl, —C(O)(CH2)mR10, —SO2(CH2)nR10, or —(CH2)pR10, where m and n are 0, 1, or 2, p is 0, 1, 2 or 3, and R10 is selected from the group consisting of (C1–C8)alkyl, a partially or fully saturated cycloalkyl, aryl, heteroaryl, and a partially or fully saturated heterocycle, where said (C1–C8)alkyl, said cycloalkyl, said aryl, said heteroaryl and said heterocycle are optionally substituted with one or more substituents;
- a pharmaceutically acceptable salt thereof, a prodrug of said compound or said salt, or a solvate or hydrate of said compound, said salt or said prodrug.
6 more elements
The compound selected from the group consisting of
- 2-(Benzyl-isopropyl-amino)-1-[1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazol-3-yl]-ethanone hydrochloride salt;
- 2-(Benzyl-isopropyl-amino)-1-[1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazol-3-yl]-ethanol;
- 2-(Benzyl-isopropyl-amino)-1-[1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazol-3-yl]-ethanol hydrochloride;
- 2-[Benzyl-(2-hydroxy-ethyl)-amino]-1-[5-(4-chlorophenyl)-1-(2-chlorophenyl)-4-methyl-1H-pyrazol-3-yl]-ethanol;
- 1-Benzylamino-1-[5-(4-chlorophenyl)-1-(2-chlorophenyl)-4-methyl-1H-pyrazol-3-yl]-ethanol hydrochloride;
- benzyl-{2-[1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazol-3-yl]-2-methoxy-ethyl}-isopropyl-amine;
- and
- 1-(Benzyl-isopropyl-amino)-2-[1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazol-3-yl]-propan-2-ol;
- or a pharmaceutically acceptable salt thereof or a solvate or hydrate of said compound or said salt.
6 more elements
Dependencies are inferred from the claim text.