Sixteen-member macrolide antiinfective agents

A compound having a structure according to formula I

• and the pharmaceutically acceptable salts thereof,
• wherein
• R2 is CHO or
• R3 is H, CH2OH,
• R4 is MeO or Me;
• R5 is H or Me;
• R6 is Me or Et;
• R7 is H or C1-C4 alkyl;
• R8 and R9 are independently H, (C1-C4)alkyl, CH2OH, or CH2O(C1-C4)alkyl, or R8 and R9 combine to form (CHR10)m;
• each R10 is independently H, OH, O(C1-C4)alkyl, or (C1-C4)alkyl;
• Ar is an unsubstituted or substituted aromatic moiety selected from the group consisting of phenyl,
• wherein a substituted aromatic moiety Ar has one to three substituents independently selected from the group consisting of halo, hydroxy, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, trifluoromethyl, cyano, nitro, C1-C3 alkylamino or dialkylamino, and C1-C3 alkoxy;
• and
• Ar1 is phenyl or phenyl substituted with one to three substituents independently selected from the group consisting of halo, hydroxy, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, trifluoromethyl, cyano, nitro, C1-C3 alkylamino or dialkylamino, and C1-C3 alkoxy;
• m is 1, 2, 3, or 4;
• and
• n is 0, 1, or 2;
• subject to
• a first proviso (I) that when (a) R1 is other than
• (b) R2 is CHO, and (c) R3is other than
• then Ar is other than unsubstituted or substituted phenyl;
• and
• a second proviso (II) that when (a) R1 is H and (b) R2 is CHO, then R3 is