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AssigneesHenry Ford Health System, Wayne State University
InventorsJae Ho Kim, Stephen Lawrence Brown, Paul S. Swerdlow
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According to the present invention, there is provided a delivery vehicle including sickle red blood cells carrying a moiety. The moiety can be any type of diagnostic or therapeutic agent. The present invention further provides for a method of diagnosing systemic hypoxia, acidosis, or hypertonicity by administering sickle red blood cells to a patient and detecting the location of the sickle red blood cells. Additionally, the present invention provides for a method of therapeutic treatment of systemic hypoxia, acidosis, or hypertonicity by administering sickle red blood cells to a patient. Further, the present invention provides for a delivery vehicle that specifically localizes or concentrates at systemic hypoxia, acidosis, or hypertonicity areas. The delivery vehicle is used in diagnosing and therapeutically treating these areas of hypoxia, acidosis, or hypertonicity also. The present invention further provides for a method of making the delivery vehicle described herein.
A method of diagnosing tumor microenvironment areas characterized by hypoxia, acidosis, and hypertonicity comprising the steps of administering sickle red blood cells to a patient and detecting the location of accumulated sickle red blood cells, whereby the sickle red blood cells accumulate at a tumor microenvironment.
A method of delivering a therapeutic agent to a solid tumor characterized by hypoxia, acidosis, and hypertonicity comprising loading the therapeutic agent into sickle red blood cells and administering the sickle red blood cells including the therapeutic agent into the blood circulation of a patient wherein the sickle red blood cells, including the therapeutic agent, accumulate in the tumor.
Dependencies are inferred from the claim text.