Method for producing dendritic cells
AssigneeIsis Innovation Limited
InventorsHerman Waldmann, Paul J. Fairchild, Richard Gardner, Frances Brook
Life of this patent
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Abstract
Disclosed are embryonic stem cell-derived dendritic cells, genetically modified immature dendritic cells capable of maturation, as well as methods for the production of such cells. In one embodiment, the cells made be produced by a method comprising the steps of providing a population of embryonic stem cells; culturing the embryonic stem cells in the presence of a cytokine or combination of cytokines which brings about differentiation of the embryonic stem cells into dendritic cells; and recovering the dendritic cells from the culture. In a further embodiment, the cells may be genetically modified.
Claims38
A process for producing a culture of human dendritic cells, comprising:
- culturing embryoid bodies made from human embryonic stem cells, said culturing being in the presence of a composition comprising IL-3;
- and recovering human dendritic cells from said culture.
A process for producing a culture of mouse dendritic cells, comprising:
- culturing embryoid bodies made from mouse embryonic stem cells, said culturing being in the presence of a composition comprising IL-3;
- and recovering mouse dendritic cells from said culture.
Dependencies are inferred from the claim text.