Flea peritrophin nucleic acid molecules, proteins and uses thereof
AssigneeHeska Corporation
InventorsPatrick J. Gaines, Nancy Wisnewski
Life of this patent
Estimating the term…
Abstract
The present invention relates to flea peritrophin proteins; to flea peritrophin nucleic acid molecules, including those that encode such flea peritrophin proteins; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain and use such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such inhibitory compounds, particularly those that specifically inhibit flea peritrophin activity, as well as the use of such therapeutic compositions to treat animals.
Claims11
An isolated flea cDNA or a flea RNA molecule selected from the group consisting of:
- (a) a flea cDNA or a flea RNA that encodes a protein having the amino acid sequence of SEQ ID NO:
- 12 and variants thereof that are at least 95% identical to SEQ ID NO:
- 12 and have peritrophin function;
- and (b) a flea cDNA or a flea RNA comprising a nucleic acid sequence fully complementary to a nucleic acid molecule of (a).
A method to produce a protein encoded by an isolated flea cDNA or a flea RNA molecule that that encodes a protein having the amino acid sequence of SEQ ID NO:12 and variants thereof that are at least 95% identical to SEQ ID NO:12 and have peritrophin function, said method comprising culturing a cell transformed with a nucleic acid molecule encoding said protein.
An isolated nucleic acid molecule SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:13, SEQ ID NO:14 or SEQ ID NO:15.
Dependencies are inferred from the claim text.