Method of screening preventives or remedies for obesity
AssigneeTakeda Pharmaceutical Company Limited
InventorsMasaaki Mori, Yukio Shimomura, Mika Goto
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Abstract
The present invention provides preventive/therapeutic agents for anorexia nervosa and preventive/therapeutic agents for obesity. More specifically, the present invention provides a method and kit for screening a compound or its salt that changes the binding properties of GPR7 to a polypeptide capable of binding specifically to GPR7.
Claims4
A method of screening a compound or its salt that alters the binding property between (1) a receptor protein or its salt containing an amino acid sequences of SEQ ID NO:
- 129 and (2) a polypeptide which specifically binds to the receptor protein, or its amide or ester, or a salt thereof, which method comprises:
- (i) contacting the polypeptide or its amide or ester, or a salt thereof with the receptor protein or its salt,
- (ii) contacting the polypeptide or its amide or ester, or a salt thereof and a test compound with the receptor protein or its salt, and
- (iii) (a) a binding amount of the polypeptide, or its amide or ester, or a salt thereof to the receptor protein or its salt of the (i) and (ii), or (b) a cell-stimulating activity of the (i) and (ii) is assayed and compared.
A kit for screening a compound or its salt that alters the binding property between (1) a protein or its salt containing an amino acid sequence represented by SEQ ID NO:129 and (2) a polypeptide which specifically binds to the protein, or its amide or ester, or a salt thereof, comprising (1) the protein or its salt and (2) the polypeptide or its amide or ester, or a salt thereof.
Dependencies are inferred from the claim text.