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US 7,247,314 B2Granted
Biocompatible material composition adaptable to diverse therapeutic indications
AssigneeNeoMend, Inc.
InventorsOlexander Hnojewyj, Charles F. Milo, Gregory M Cruise
Life of this patent
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Abstract
A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.
Claims18
A method comprising
- providing a protein solution,
- providing a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three,
- mixing the protein solution and the polymer solution, the protein solution and the polymer solution cross-linking to form a non-liquid hydrogel composition having a degradation time in situ that is from 1 week to 6 months,
- selecting a therapeutic agent comprising cells, and
- causing the therapeutic agent to become incorporated into the hydrogel composition, the degradation time being within a desired time frame for the cells to remodel tissue.
2 more elements
A method comprising
- providing a protein solution,
- providing a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three, the polymer solution comprising 17% w/w 4-arm poly(ethylene glycol) tetra-succinimidyl glutarate, MW 10,000, in water,
- mixing the protein solution and the polymer solution, the protein solution and the polymer solution cross-linking to form a non-liquid hydrogel composition,
- selecting a therapeutic agent, and
- causing the therapeutic agent to become incorporated into the hydrogel composition.
2 more elements
A method comprising
- providing a protein solution comprising 25% w/w albumin supplemented with 75 mM sodium carbonate and 75 mM sodium bicarbonate,
- providing a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three,
- mixing the protein solution and the polymer solution, the protein solution and the polymer solution cross-linking to form a non-liquid hydrogel composition,
- selecting a therapeutic agent, and
- causing the therapeutic agent to become incorporated into the hydrogel composition.
2 more elements
Dependencies are inferred from the claim text.