Tumor vaccines
AssigneesCell-Medicine, Inc., Riken
InventorsTadao Ohno, Bao Gang Peng, Kam Leong, Shu Qin Liu
Life of this patent
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Abstract
A tumor vaccine which comprises a microparticle or a lysate prepared from a solidified tumor material selected from the group consisting of a tumor tissue, a tumor cell, and a component thereof, and at least one cytokine and/or cytokine-inducing agent (e.g., a granulocyte-macrophage-colony stimulating factor and/or interleukin-2 and the like), and optionally an adjuvant. The vaccine can be easily prepared and widely applied for prevention of recurrence, inhibition of metastasis and therapeutic treatment regardless of a type of a tumor, and has excellent antitumor effect.
Claims18
A tumor vaccine comprising:
- (A) a microparticle comprising a fragment of solidified, chemically fixed tumor tissues or cells, said fragment being of a size so as to allow phagocytosis of the fragment;
- and
- (B) at least one isolated cytokine, at least one isolated compound that is a cytokine-inducing agent, or a combination thereof.
A tumor vaccine for use in combination with at least one isolated cytokine, the vaccine comprising, as an active ingredient, a microparticle comprising a fragment of solidified, chemically fixed tumor tissues or cells, said fragment being of a size so as to allow phagocytosis of the fragment.
Dependencies are inferred from the claim text.