Radiation therapy by accumulation of therapeutic radionuclides in tumor-targeting bacteria
AssigneeMDS (Canada) Inc.
InventorRussell Redshaw
Life of this patent
Estimating the term…
Abstract
The invention can be summarized as follows. According to the present invention there is provided an attenuated, tumour-targeting bacterium comprising a heterologous nucleotide sequence encoding a protein permitting the accumulation of a radionuclide within the bacterium. The heterologous nucleotide sequence may encode a sodium iodide symporter protein. The invention also relates to the use of such bacteria and methods of treating diseases using the bacteria of the present invention.
Claims6
A method of treating a tumor in a subject, comprising administering to the subject an attenuated, tumour-targeting bacterium comprising a heterologous nucleotide sequence comprising a sodium iodide symporter (NIS) gene encoding a protein that promotes accumulation of a radionuclide within the bacterium.
A method of treating a tumor in a subject comprising the steps of:
- i) administering to the subject an attenuated, tumour-targeting bacterium specific for the tumor, the bacterium comprising a heterologous nucleotide sequence comprising a sodium iodide symporter (NIS) gene encoding a protein that promotes accumulation of a radionuclide within the bacterium, and
- ii) administering to the subject a therapeutically effective amount of the radionuclide.
A method of treating a tumor in a subject, comprising administering to the subject an attenuated, tumor targeting bacterium comprising a heterologous nucleotide sequence comprising a sodium iodide symporter (NIS) gene encoding a protein that promotes accumulation of a radionuclide within the bacterium, wherein the bacterium comprises a therapeutically effective amount of the radionuclide.
Dependencies are inferred from the claim text.