Method of forming composite informational item

A method of forming a composite informational item having information regarding a pharmaceutical product printed thereon, said composite informational item comprising a first bidirectionally folded outsert releasably bonded to a second bidirectionally folded outsert, each of said first and second bidirectionally folded outserts having information regarding a pharmaceutical product printed thereon, each of said first and second bidirectionally folded outserts having a plurality of folds in two perpendicular directions, said method comprising:

• (a) forming said first bidirectionally folded outsert via a method comprising:
• (a1) folding a first sheet of paper having information regarding a pharmaceutical product printed thereon by making a plurality of folds in said first sheet of paper to form a first folded article, said folds in said first sheet of paper being parallel to each other and parallel to a first direction, said plurality of folds in said first sheet of paper being made by a folding apparatus comprising a plurality of pairs of folding rollers;
• (a2) folding said first folded article by making a plurality of folds in said first folded article to form a second folded article, said folds in said first folded article being parallel to a second direction, said second direction being perpendicular to said first direction, said plurality of folds in said first folded article being made by a folding apparatus comprising a plurality of pairs of folding rollers;
• (a3) depositing an adhesive on a portion of said second folded article;
• and
• (a4) folding said second folded article by making a fold in said second folded article to form said first bidirectionally folded outsert, said fold in said second folded article being parallel to said second direction and being made so that said adhesive holds said first bidirectionally folded outsert in a substantially closed position, said fold in said second folded article being made with a knife-type folding apparatus comprising a pair of folding rollers and a movable knife member;
• (b) automatically conveying said first bidirectionally folded outsert from a location in a first feed apparatus to a bonding location;
• (c) providing a plurality of said second bidirectionally folded outserts in a second feed apparatus different than said first feed apparatus, each of said second bidirectionally folded outserts having a plurality of folds in a first direction and a plurality of folds in a second direction perpendicular to said first direction;
• (d) automatically depositing a releasable adhesive on a face of one of said bidirectionally folded outserts;
• (e) engaging a surface of one of said second bidirectionally folded outserts disposed in a location in said second feed apparatus with a transfer device;
• (f) automatically conveying said second bidirectionally folded outsert from said location in said second feed apparatus to said bonding location by moving said transfer device;
• (g) disengaging said transfer device from said surface of said second bidirectionally folded outsert after said second bidirectionally folded outsert is conveyed to said bonding location;
• and
• (h) causing a face of said first bidirectionally folded outsert to make contact with a face of said second bidirectionally folded outsert so that said first bidirectionally folded outsert and said one second bidirectionally folded outsert are releasably bonded together via said releasable adhesive applied to said face of one of said bidirectionally folded outserts.