Stearoyl CoA desaturase transgenic non-human animals
AssigneeThe Regents of the University of California
InventorsJames D. Murray, Elizabeth A. Maga
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Abstract
The present invention provides transgenic, non-human animals that include a transgene that encodes a fatty acid desaturase, e.g., stearoyl-CoA desaturase, and methods for producing such animals. The invention further provides an expression cassette that includes a coding region for a desaturase such as stearoyl-CoA desaturase, operably linked to a heterologous, tissue-specific animal cell promoter. The invention further provides methods of producing a food product, such as milk, meat, or eggs, using a subject transgenic non-human animal, as well as food products harvested from a subject transgenic non-human animal.
Claims16
A non-human transgenic mammal whose genome comprises a transgene comprising a nucleotide sequence encoding a stearoyl coenzyme A desaturase, wherein said desaturase-encoding nucleotide sequence is operably linked to a mammary gland-specific promoter, wherein the transgene is expressed in a mammary gland epithelial cell of said mammal, and wherein said mammal produces milk comprising a level of monounsaturated fatty acids (MUFA) that is at least 5% higher than the level of MUFA in milk produced by a non-transgenic mammal of the same species.
Dependencies are inferred from the claim text.