Carboxamido opioid compounds
AssigneeJanssen Pharmaceutical N.V.
InventorsJohn R. Carson, Philip M. Pitis
Life of this patent
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Abstract
This invention is directed to carboxamido opioid compounds pharmaceutically useful as agents for treating or modulating a central nervous system disorder and methods for treating or modulating a central nervous system disorder.
Claims18
A composition comprising a compound of Formula (I)
- wherein:
- R1 and R2 are independently selected from the group consisting of hydrogen, lower alkyl, and alkyldiyl wherein R1 and R2 are taken together with the atoms to which they are attached to form a monocyclic ring;
- R3 and R4 are independently selected from the group consisting of hydrogen, lower alkyl, C3-7cycloalkyl, and alkyldiyl wherein R3and R4 are taken together with the atoms to which they are attached to form a monocyclic ring;
- Y is hydrogen, lower alkyl, lower alkoxy, halogen, or trifluoromethyl;
- and pharmaceutically acceptable enantiomers, diastereomers, tautomers, solvates and salts thereof.
A compound selected from the group consisting of
- 3-[(1-RS,2-SR)-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-benzamide;
- 3-[(1-RS,2-RS)-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-benzamide;
- (−)-3-[(1R,2R)-rel-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-benzamide;
- (+)-3-[(1S,2S)-rel-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-benzamide;
- 3-[(1-RS,2-RS)-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-N,N-diethyl-benzamide;
- N-cyclopropyl-3-[(1-RS,2-RS)-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-benzamide;
- and
- 3-[(1-RS,2-RS)-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-N-methylbenzamide.
A compound selected from the group consisting of (−)-3-[(1R,2R)-rel-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-benzamide and (+)-3-[(1S,2S)-rel-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-benzamide.
The compound (+)-3-[(1S,2S)-rel-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-benzamide.
Dependencies are inferred from the claim text.