Replicons of pestviruses that do not express C and or E1 protein and infectious viral particles containing same, that can be used in vaccines
AssigneeIntervet International B.V.
InventorsMartin Beer, Ilona Reimann
Life of this patent
Estimating the term…
Abstract
The present invention provides new Pestiviral RNA genomes (replicons) that are able to replicate, and can be packaged into infectious viral particles in cells that complement the missing protein(s), but do not produce infectious progeny virus. Such replicons can be useful for vaccine purposes.
Claims9
A replicon of a pestivirus which is incapable of expressing one or more structural proteins of the virus, characterized in that said replicon expresses all structural proteins of a pestivirus except for a functional C protein, but wherein the coding sequences encoding a signal sequence within the C protein essential for post translational processing are retained or replaced by a coding sequence encoding analogous signal sequences from another pestiviral species.
Dependencies are inferred from the claim text.