Adenovirus comprising a gene coding for glutathione peroxidase
AssigneeAventis Pharma S.A.
InventorsMartine Barkats, Jacques Mallet, Frédéric Revah
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Abstract
The present invention relates to a defective adenovirus comprising at least a DNA sequence coding for all or an active part of glutathione peroxidase or a derivative thereof. It also relates to their utilization in therapy and to the corresponding pharmaceutical compositions.
Claims4
A cultured human glial cell infected with a replication defective recombinant Ad5 human adenovirus, wherein said adenovirus comprises a cDNA sequence encoding a human glutathione peroxidase under the control of an RSV LTR promoter controlling expression in a glial cell, a sequence permitting encapsidation, and wherein an adenoviral E1 gene and at least one of the adenoviral L1–L5 genes are not functional.
Dependencies are inferred from the claim text.