# US 7,241,449 B1 · Transferrin receptor genes of moraxella

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- Number: US 7,241,449 B1
- Document ID: US7241449B1
- Status: Granted
- Kind: B1
- Application number: 09/673,133
- Filed: 1999-04-12
- Granted: 2007-07-10
- Earliest claimed: 1999-04-12
- Assignees: Aventis Pasteur Limited
- Inventors: Lisa E. Myers; Anthony B. Schryvers; Robin E. Harkness; Sheena M. Loosmore; Run-Pan Du; Yan-Ping Yang; Michel H. Klein
- Web page: https://patentgrep.com/patent/US7241449B1

## CPC

- C07K 14/212: {Moraxellaceae, e.g. Acinetobacter, Moraxella, Oligella, Psychrobacter}
- A61K 39/00: Medicinal preparations containing antigens or antibodies (materials for immunoassay G01N33/53)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Purified and isolated nucleic acid molecules are provided which encode Tbp2 proteins of M. catarrhalis strains M35, 3 and LES1. The nucleic acid sequence may be used to produce recombinant Tbp2 proteins of the strain of Moraxella free of other proteins of the Moraxella strain for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecules may be used in the diagnosis of infection.

## Claims

### Claim 1

A recombinant Tbp2 protein of Moraxella catarrhalis strain M35, 3 or LES1, having a deduced amino acid sequence selected from the group consisting of those shown in FIGS. 2, 4 or 6 (SEQ ID NO: 2, 4 or 6).

### Claim 2 (depends on 1)

An immunogenic composition, comprising at least one active component selected from the group consisting of the recombinant Tbp2 proteins claimed in claim 1; and a pharmaceutically carrier therefor, said at least one active component producing an immune response when administered to a host.

### Claim 3 (depends on 2)

A method for generating an immune response in a host, comprising administering to the host an immunoeffective amount of an immunogenic composition selected from the group consisting of the immunogenic compositions claimed in claim 2.

### Claim 4 (depends on 1)

A recombinant transferrin receptor protein of claim 1 for use as a medicine.