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US 7,241,309 B2Granted
Self-aggregating protein compositions and use as sealants
AssigneeSciMed Life Systems, Inc.
InventorsDan Castro, Al Kuehn, Moon Hae Sunwoo
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Abstract
There is described a bio-compatible aqueous slurry for forming a fluid-tight barrier on a surface of a porous implantable article. This aqueous slurry includes a self-aggregating protein comminutate having a substantially uniform particle size, a bio-compatible plasticizer and water. This aqueous slurry is further characterized by having a viscosity of about 8,000 centipoise to about 60,000 centipoise at 25° C. and a pH sufficient to maintain the protein suspended in the slurry.
Claims17
An implantable member for use in the body comprising:
- a porous biocompatible substrate;
- and
- an aqueous non-crosslinked sealant composition in intimate contact with said porous substrate for forming a substantially fluid-tight seal, wherein said sealant composition forms said substantially fluid-tight seal in absence of cross-linking, said sealant composition comprising:
- a self-aggregating protein comminutate composition comprising particles of substantially the same diameter and water;
- wherein said protein composition has a pH sufficient to maintain said protein comminutate in particulate form.
2 more elements
Dependencies are inferred from the claim text.