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US 7,241,272 B2Granted
Method and composition for removing uremic toxins in dialysis processes
AssigneeBaxter International Inc.
InventorsSujatha Karoor, Brian Donovan, Ton That Hai, Mari Katada, Luis Lu, Leo Martis, Stavroula Morti, Salim Mujais, Paul J. Sanders, Paul J. Soltys, Rahul Tandon
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Abstract
Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.
Claims16
A device for removing uremic toxins in a dialysis procedure comprising:
- a body having an inlet and an outlet and defining an interior, the interior including a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon;
- and
- the device being so constructed and arranged so that a fluid entering the device contacts the zirconium phosphate layer upon entering the device before contacting the urease or the zirconium oxide layer.
A device for removing uremic toxins in a dialysis procedure comprising:
- a body having an inlet and an outlet and defining an interior, the interior including a layer comprising a modified urease selected from the group consisting of cross-linked enzyme crystals of urease, a blend of urease and zirconium oxide, and alumina-stabilized urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon;
- and
- the device being so constructed and arranged so that a fluid entering the device contacts the zirconium phosphate layer upon entering the device before contacting the modified urease or the zirconium oxide layer.
A device for removing uremic toxins in a dialysis procedure comprising:
- a body having an inlet and an outlet and defining an interior, the interior including a layer comprising a modified urease selected from the group consisting of cross-linked enzyme crystals of urease, a blend of urease and zirconium oxide, and alumina-stabilized urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon wherein the modified urease is an irradiated modified urease.
A device for removing uremic toxins in a dialysis procedure comprising:
- a body having an inlet and an outlet and defining an interior, the interior including a layer comprising a modified urease selected from the group consisting of cross-linked enzyme crystals of urease, a blend of urease and zirconium oxide, and alumina-stabilized urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon wherein the modified urease is a blend of urease and zirconium oxide, the urease present from about 0.1% to about 0.2% by weight of the blend.
Dependencies are inferred from the claim text.