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AssigneesOsaka Bioscience Institute, Riken
InventorsYoshihiro Urade, Naomi Eguchi, Kosuke Aritake, Yo Sato, Masako Taniike, Ikuko Mori, Masashi Miyano
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An object of the present invention is to provide a method which is able to prevent or improve the progress of myolytic diseases such as muscular dystrophy. Such an object is able to be solved by a method where an effective dose of an inhibitor for hematopoietic prostaglandin D synthase (H-PGDS) or an antagonist to prostaglandin D receptor is administered to a patient who needs it. The present invention also provides a method for screening compounds which are able to prevent the progress of myolytic diseases and to improve it using human H-PGDS overexpressed transgenic mice.
A method for treatment of Duchenne's dystrophy (DMD) or polymyositis (PM), comprising
A method for treatment of polymyositis (PM) where an effective dose of an antagonist to prostaglandin D receptor is administered to a patient who needs it.
Dependencies are inferred from the claim text.