Vaccine against Gram-negative bacterial infections
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsApurba Bhattacharjee, Alan Cross, Jerald Sadoff, Wendell Zollinger
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Abstract
A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LPS derived from E. coli and purified outer membrane protein derived from N. meningitidis. The same vaccine will also actively immunize a host subject against Gram-negative bacterial infections and LPS-mediated pathology. Meningococcal infections are included among those Gram-negative bacterial infections protected against by the vaccine.
Claims7
A post-immune serum, plasma, or IgG each isolated from a subject immunized with a vaccine comprising a non-covalent complex of a purified, detoxified lipopolysaccharide endotoxin of Escherichia coli J5 strain and a purified outer membrane protein of Neisseria meningitidis.
Dependencies are inferred from the claim text.