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US 7,228,159 B2Granted
Optical sensor containing particles for in situ measurement of analytes
AssigneePrecisense A/S
InventorsBo Petersson, Jesper Kristensen
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AssigneePrecisense A/S
InventorsBo Petersson, Jesper Kristensen
Estimating the term…
The invention relates to a sensor for the in vivo measurement of an analyte, comprising a plurality of particles of suitable size such that when implanted in the body of a mammal the particles can be ingested by macrophages and transported away from the site of implantation, each particle containing the components of an assay having a readout which is an optical signal detectable transdermally by external optical means, and either each particles being contained within a biodegradable material preventing ingestion by the macrophages, or each particle being non-biodegradable. The invention relates to a process for the detection of an analyte using such a sensor, comprising implantation of the sensor into the skin of a mammal, transdermal detection of analyte using external optical means, degradation of the biodegradable material, ingestion of the particles by macrophages, and removal of the particles from the site of implantation by macrophages.
A sensor for in vivo measurement of an analyte, comprising a plurality of particles having a size such that when implanted in a body of a mammal at an implantation site the particles can be ingested by macrophages and transported away from the implantation site, wherein each particle of the sensor contains the components of an assay having a readout which is an optical signal detectable transdermally by external optical means, and wherein the particles are each contained within a biodegradable material preventing ingestion by the macrophages.
A sensor for in vivo measurement of an analyte, comprising a plurality of particles having a size such that when implanted in a body of a mammal at an implantation site the particles can be ingested by macrophages and transported away from the implantation site, wherein each particle of the sensor contains the components of an assay having a readout which is an optical signal detectable transdermally by external optical means, and wherein the particles are each contained within a biodegradable material preventing ingestion by the macrophages, the biodegradable material being a gel.
Dependencies are inferred from the claim text.