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US 7,227,042 B2Granted
Method of preparing 1-acetyl-1-chlorocyclopropane
AssigneeBayer CropScience AG
InventorsJoe J. Hanson, David M. Mayes, Klaus Stroech, Shekhar V. Kulkarni
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Abstract
The present invention provides a method of preparing 1-acetyl-1-chlorocyclopropane from 1,3 dichloro-2-pentanone by reaction with base in the presence of a phase transfer catalyst. The reaction may be run in the presence or absence of an organic solvent and in a continuous or batch process.
Claims26
A method of preparing 1-acetyl-1-chlorocyclopropane which comprises
- (a) providing 3,5-dichloro-2-pentanone;
- (b) providing a phase transfer catalyst selected from the group consisting of tetraalkylammonium halides and aryltrialkylammonium halides;
- (c) providing an aqueous solution of a base selected from the group consisting of bases whose conjugate acids have a pKa value in water of from about 8 to about 15;
- (d) admixing 3,5-dichloro-2-pentanone, the phase transfer catalyst, and the aqueous solution of the base at a temperature above room temperature in the absence of an organic solvent for a time sufficient to form 1-acetyl-1-chlorocyclopropane;
- and
- (e) separating the 1-acetyl-1-chlorocyclopropane.
3 more elements
A method of preparing 1-acetyl-1-chlorocyclopropane which comprises
- (a) providing 3,5-dichloro-2-pentanone;
- (b) providing a phase transfer catalyst selected from the group consisting of tetraalkylammonium halides and aryltrialkylammonium halides;
- (c) providing an aqueous solution of a base selected from the group consisting of bases whose conjugate acids have a pKa value in water of from about 8 to about 15;
- (d) admixing 3,5-dichloro-2-pentanone, the phase transfer catalyst, and the aqueous solution of a base at a temperature above room temperature in the presence of an organic solvent that is substantially immiscible in water for a time sufficient to form 1-acetyl-1-chlorocyclopropane;
- and
- (e) separating the 1-acetyl-1-chlorocyclopropane.
3 more elements
Dependencies are inferred from the claim text.