Sodium channel modulators

A compound of formula (III):

• wherein:
• A6 and A7 are each independently alkylene or substituted alkylene;
• each R20 is independently halo, alkyl, substituted alkyl, aryl, alkoxy, substituted alkoxy, cycloalkoxy, substituted cycloalkoxy, trifluoromethyl, cyano, nitro, hydroxy, NR4R5, or CO2R6;
• R21 is hydrogen, alkyl, or substituted alkyl;
• each R22 is independently halo, alkyl, substituted alkyl, aryl, heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycle, alkoxy, substituted alkoxy, cycloalkoxy, substituted cycloalkoxy, trifluoromethyl, cyano, nitro, hydroxy, NR4R5, or CO2R6;
• y is 0, 1, 2, 3, 4, or 5;
• z is 0, 1, 2, 3, 4, or 5;
• and
• R4–R6 are each independently hydrogen, alkyl, or substituted alkyl;
• wherein any aryl of A6, A7, R20–R22 and R4–R6 can optionally be substituted with from 1 to 5 substituents Rg;
• wherein each Rg is independently selected from the group consisting of hydroxy, alkyl, substituted alkyl, alkoxy, cycloalkoxy, substituted cycloalkoxy, methanediol, ethanediol, cycloalkyl, substituted alkoxy, substituted cycloalkyl, amino, substituted amino, aryl, aryloxy, carboxy, carboxylalkyl, carboxyl(substituted alkyl), cyano, halo, nitro, heteroaryl, heteroaryloxy, heterocyclic, heterocyclooxy, heteroaryl and trihalomethyl;
• and wherein any heteroaryl of A6, A7, R20–R22 and R4–R6 can be optionally substituted with 1 to 5 substituents Rh, wherein each Rh is independently selected from the group consisting of hydroxy, alkyl, alkoxy, substituted alkoxy, cycloalkoxy, substituted cycloalkoxy, substituted alkyl, arylalkyl, heteroarylalkyl, heterocyclealkyl, substituted cycloalkyl, amino, substituted amino, aryl, aryloxy, carboxyl, carboxylalkyl, carboxyl(substituted alkyl), cyano, halo, nitro, heterocyclic, and trihalomethyl;
• or a pharmaceutically acceptable salt thereof.