Cardiac muscle function and manipulation
AssigneeZensun (Shanghai) Science & Technology, Co., Ltd.
InventorMingdong Zhou
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Abstract
A method of causing cardiomyocyte growth and/or differentiation, the method comprising exposing a cardiomyocyte to neuregulin (NRG) thereby activating the MAP kinase pathway in the cardiomyocyte and causing growth and/or differentiation of the cardiomyocyte. Use of neuregulin, neuregulin polypeptide, neuregulin derivatives, or compounds which mimic the activities of neuregulins in the treatment or management of heart disease and heart failure in a mammal.
Claims28
A method of inducing remodeling of cardiac muscle cell sarcomeric and cytoskeleton structures or cell-cell adhesions, which method comprises contacting cardiac muscle cells with a neuregulin protein consisting of the amino acid sequence set forth in SEQ ID NO:2, in the amount sufficient to activate the MAP kinase pathway in said cardiac muscle cells and induce remodeling of said cardiac muscle cell sarcomeric and cytoskeleton structures or cell-cell adhesions.
A method for treating or delaying disassociation of cardiac muscle cell-cell adhesion and/or the disarray of sarcomeric structures in a mammal, which method comprises administering to a mammal, to which such treatment or delay is needed or desirable, a neuregulin protein consisting of the amino acid sequence set forth in SEQ ID NO:2, in an amount sufficient to activate the MAP kinase pathway in said mammal, whereby said disassociation of cardiac muscle cell-cell adhesion and/or the disarray of sarcomeric structures is treated or delayed in said mammal.
Dependencies are inferred from the claim text.